The Info-Tech Storage Format (ITSF) is the primary format that has been adopted by Microsoft for online help files since Windows 98. Due to its popularity, it has been used (and exploited) by many other third parties, mostly because of the support provided by documentation utilities like Doxygen.
With the upcoming 0.8.0 release, the Profiler comes with full compatibility for the following file extensions: CHM, CHI, CHQ, CHW, KPD.
Despite the name (Microsoft Compiled HTML Files), the image above shows the Profiler analyzing a CHM containing not only HTML, but also fonts and PDF documents. These files tend to contain a lot of information, and may require you to increase the unpack limit from the settings.